K/U: Knowledge and Understanding T/I: Thinking and Investigation C: Communication A: Application
For each question, select the best answer from the four alternatives.
1. Which best describes the structure of human DNA? (6.1) K/U (a) two parallel, identical strands of nucleotides (b) two strands of nucleotides that intertwine in opposite directions to form a corkscrew pattern (c) two identical copies of a chain of nucleotides linked to form a single, long strand (d) circular, interconnected chains of nucleotides
2. Which molecule would form a complementary bond with a cytosine molecule in DNA? (6.1) K/U (a) another cytosine molecule (b) an adenine molecule (c) a guanine molecule (d) a thymine molecule
3. Which mutation would be classified as induced? (6.2) K/U (a) crossing over during meiosis (b) a copying error during chromosome replication (c) a non-disjunction error during meiosis (d) a gene permanently damaged by the chemicals in cigarette smoke
4. Which disease or disorder shows how mutations can be both beneficial and harmful? (6.2) K/U (a) Down syndrome (b) cystic fibrosis (c) muscular dystrophy (d) sickle-cell anemia
5. In which situation is DNA fingerprinting most commonly used? (6.3) K/U (a) providing forensic evidence in criminal cases (b) providing evidence in paternity suits (c) identifying unknown remains (d) establishing ancestral lines
6. A genetically engineered organism was created to produce a desired product. Consider the possible events below (given in no particular order). (i) foreign gene and plasmid combined (ii) foreign gene-produced product (iii) DNA cuts made with restriction enzymes (iv) recombinant plasmid taken up by a bacterium Which is their most likely sequence? (6.4) T/I A (a) iii, ii, iv, i (b) i, iii, iv, ii (c) iii, i, iv, ii (d) ii, i, iv, iii
7. Which statement is true of viruses used to introduce genes into human cells? (6.5) K/U (a) They must be altered so they do not cause disease. (b) They are never attacked by the host's immune system. (c) They always insert genes precisely in the same place. (d) They only succeed when they contain plasmids.
8. Which description best characterizes the current state of gene therapy? (6.5) T/I (a) relatively new; some successes and some failures (b) well established; used in many treatments (c) not considered to have much potential (d) no successes yet; only failures
Indicate whether each statement is true or false. If you think the statement is false, rewrite it to make it true.
9. Of the possible point mutations, base-pair substitution is likely to have the smallest impact on the assembly of proteins by ribosomes. (6.2) T/I
10. A mutation can be inherited if it occurs in a somatic cell. (6.2) K/U
11. Barbara McClintock experimented with mutations in corn caused by ultraviolet radiation. (6.2) K/U
12. An infection that does not respond to antibiotics is likely caused by a resistant virus. (6.2) A
13. The nucleotide sequence ATCGGGTAT would be complementary to TAGCCCATA. (6.2) T/I
14. The human genome consists of about 3 million base pairs. (6.3) K/U
15. Mice are a good genetic model for humans. (6.3) K/U
16. The greatest proportion of DNA in humans is coding. (6.3) K/U
17. The BamHl restriction enzyme would be able to cut the segment of DNA shown here: (6.4) T/I AATGGATCTACC TTACCTAGATGG
18. Bt corn is genetically engineered to make its own herbicide. (6.4) K/U
19. Agrobacterium tumefaciens is often used to insert genes into plants. (6.4) K/U
SELF-QUIZ
Key
K/U: Knowledge and Understanding
T/I: Thinking and Investigation
C: Communication
A: Application
For each question, select the best answer from the four alternatives.
1. Which best describes the structure of human DNA? (6.1) K/U
(a) two parallel, identical strands of nucleotides
(b) two strands of nucleotides that intertwine in opposite directions to form a corkscrew pattern
(c) two identical copies of a chain of nucleotides linked to form a single, long strand
(d) circular, interconnected chains of nucleotides
2. Which molecule would form a complementary bond with a cytosine molecule in DNA? (6.1) K/U
(a) another cytosine molecule
(b) an adenine molecule
(c) a guanine molecule
(d) a thymine molecule
3. Which mutation would be classified as induced? (6.2) K/U
(a) crossing over during meiosis
(b) a copying error during chromosome replication
(c) a non-disjunction error during meiosis
(d) a gene permanently damaged by the chemicals in cigarette smoke
4. Which disease or disorder shows how mutations can be both beneficial and harmful? (6.2) K/U
(a) Down syndrome
(b) cystic fibrosis
(c) muscular dystrophy
(d) sickle-cell anemia
5. In which situation is DNA fingerprinting most commonly used? (6.3) K/U
(a) providing forensic evidence in criminal cases
(b) providing evidence in paternity suits
(c) identifying unknown remains
(d) establishing ancestral lines
6. A genetically engineered organism was created to produce a desired product. Consider the possible events below (given in no particular order).
(i) foreign gene and plasmid combined
(ii) foreign gene-produced product
(iii) DNA cuts made with restriction enzymes
(iv) recombinant plasmid taken up by a bacterium Which is their most likely sequence? (6.4) T/I A
(a) iii, ii, iv, i
(b) i, iii, iv, ii
(c) iii, i, iv, ii
(d) ii, i, iv, iii
7. Which statement is true of viruses used to introduce genes into human cells? (6.5) K/U
(a) They must be altered so they do not cause disease.
(b) They are never attacked by the host's immune system.
(c) They always insert genes precisely in the same place.
(d) They only succeed when they contain plasmids.
8. Which description best characterizes the current state of gene therapy? (6.5) T/I
(a) relatively new; some successes and some failures
(b) well established; used in many treatments
(c) not considered to have much potential
(d) no successes yet; only failures
Indicate whether each statement is true or false. If you think the statement is false, rewrite it to make it true.
9. Of the possible point mutations, base-pair substitution is likely to have the smallest impact on the assembly of proteins by ribosomes. (6.2) T/I
10. A mutation can be inherited if it occurs in a somatic cell. (6.2) K/U
11. Barbara McClintock experimented with mutations in corn caused by ultraviolet radiation. (6.2) K/U
12. An infection that does not respond to antibiotics is likely caused by a resistant virus. (6.2) A
13. The nucleotide sequence ATCGGGTAT would be complementary to TAGCCCATA. (6.2) T/I
14. The human genome consists of about 3 million base pairs. (6.3) K/U
15. Mice are a good genetic model for humans. (6.3) K/U
16. The greatest proportion of DNA in humans is coding. (6.3) K/U
17. The BamHl restriction enzyme would be able to cut the segment of DNA shown here: (6.4) T/I
AATGGATCTACC
TTACCTAGATGG
18. Bt corn is genetically engineered to make its own herbicide. (6.4) K/U
19. Agrobacterium tumefaciens is often used to insert genes into plants. (6.4) K/U