What Causes Heart Valve Disease?
Heart valve disease can develop before birth (congenital) or can be acquired sometime during one's lifetime. Sometimes, the cause of valve disease is unknown.
Congenital valve disease. This form of valve disease most often affects the aortic or pulmonic valve. Valves may be the wrong size, have malformed leaflets, or have leaflets that are not attached correctly.
Bicuspid aortic valve disease is a congenital valve disease that affects the aortic valve. Instead of the normal three leaflets or cusps, the bicuspid aortic valve has only two. Without the third leaflet, the valve may be stiff (unable to open or close properly) or leaky (not able close tightly).
Acquired valve disease. This includes problems that develop with valves that were once normal. These may involve changes in the structure or your valve due to a variety of diseases or infections, including rheumatic fever or endocarditis.
  • Rheumatic fever is caused by an untreated bacterial infection (usually strep throat). Luckily, this infection was much more common before the introduction of antibiotics to treat it in the 1950s. The initial infection usually occurs in children and causes inflammation of the heart valves. However, symptoms associated with the inflammation may not be seen until 20-40 years later.
  • Endocarditis occurs when germs, especially bacteria, enter the bloodstream and attack the heart valves, causing growths and holes in the valves and scarring. This can lead to leaky valves. The germs that cause endocarditis can enter the blood during dental procedures, surgery, IV drug use, or with severe infections. People with valve disease can be at higher risk for developing endocarditis.
There are many changes that can occur to the valves of the heart. The chordae tendinae or papillary muscles can stretch or tear; the annulus of the valve can dilate (become wide); or the valve leaflets can become fibrotic (stiff) and calcified.
Mitral valve prolapse (MVP) is a very common condition, affecting 1% to 2% of the population. MVP causes the leaflets of the mitral valve to flop back into the left atrium during the heart's contraction. MVP also causes the tissues of the valve to become abnormal and stretchy, causing the valve to leak. However, the condition rarely causes symptoms and usually doesn't require treatment.
Other causes of valve disease include: coronary artery disease, heart attack, cardiomyopathy (heart muscle disease), syphilis (a sexually transmitted disease), high blood pressure, aortic aneurysms, and connective tissue diseases. Less common causes of valve disease include tumors, some types of drugs, and radiation.

Symtems.
Symptoms of heart valve disease can include:
  • Shortness of breath and/or difficulty catching your breath. You may notice this most when you are active (doing your normal daily activities) or when you lie down flat in bed. You may need to sleep propped up on a few pillows to breathe easier.
  • Weakness or dizziness. You may feel too weak to carry out your normal daily activities. Dizziness can also occur, and in some cases, passing out may be a symptom.
  • Discomfort in your chest. You may feel a pressure or weight in your chest with activity or when going out in cold air.
  • Palpitations. This may feel like a rapid heart rhythm, irregular heartbeat, skipped beats, or a flip-flop feeling in your chest.
  • Swelling of your ankles, feet, or abdomen. This is called edema. Swelling in your belly may cause you to feel bloated.
  • Rapid weight gain. A weight gain of two or three pounds in one day is possible.
Symptoms of heart valve disease do not always relate to the seriousness of your condition. You may have no symptoms at all and have severe valve disease, requiring prompt treatment. Or, as with mitral valve prolapse, you may have noticeable symptoms, yet tests may show the valve leak is not significant.

Treatments.
Heart valve disease treatment depends on the type and severity of disease. There are three goals of treatment for heart valve disease: protecting your valve from further damage; lessening symptoms; and repairing or replacing valves.
Protecting your valve from further damage. If you have valve disease, you are at higher risk for developing endocarditis, a serious condition. People who have had their valve surgically repaired or replaced are also at higher risk for endocarditis.
To protect yourself:
  • Tell your doctors and dentist you have heart valve disease. You may want to carry an identification card with this information. The American Heart Association website has a bacterial endocarditis wallet card that you may download; or call your local American Heart Association office or the national office at 1-800-AHA-USA1.
  • Call your doctor if you have symptoms of an infection (sore throat, general body aches, fever).
  • Take good care of your teeth and gums to prevent infections. See your dentist for regular visits.
  • Your doctor may recommend that you take antibiotics before you undergo any procedure that may cause bleeding, such as any dental work (even a basic teeth cleaning), invasive tests (any test that may involve blood or bleeding), and most major or minor surgery. The recommendations for which procedures and which types of valve disease need antibiotics have recently changed, so make sure to ask your doctor about the latest recommendations.
Medications. You may be prescribed medications to treat your symptoms and to lessen the chance of further valve damage. Some drugs may be stopped after you have had heart valve surgery to correct the problem. Other medications may need to be taken all your life. Common heart disease drugs may include:

Heart disease drugs

What they do





Diuretics ("water pills")

Remove extra fluid from the tissues and bloodstream; lessen the symptoms of heart failure





Anti-arrhythmic medications

Control the heart's rhythm





Vasodilators

Lessen the heart's work. Also encourages blood to flow in a forward direction, rather than backwards through a leaky valve.





ACE inhibitors

A type of vasodilator used to treat high blood pressure and heart failure.





Beta blockers

Treat high blood pressure and lessen the heart's work by helping the heart beat slower and less forcefully. Used to decrease palpitations in some patients





Anticoagulants ("blood thinners")

Prolong the clotting time of your blood, if you are at risk for developing blood clots on your